ABSTRACT
Background: The Severe Acute Respiratory Coronavirus (SARS-CoV-2) has emerged in a variety of forms since its first appearance in early December 2019. The Omicron variation (B.1.1.529) was recently confirmed as a relatively new Variant of Concern (VOC). There are several mutations in this S-protein, making it an exclusively lethal version of the protein. Omicron variants feature multiple mutations clustered in a region of S protein that is the principal target of antibodies, and these mutations may have an impact on the binding affinities of antibodies to the S protein, as demonstrated by structural analysis. Materials and Methods: Google, Sciencedirect, Web of science, and ResearchGate databases have been explored for potentially existing research to obtain the most emerging trends and up-to-date metadata on various perspectives of Omicron variants. Conclusion: There is evidence that the Omicron variant's mutations may interfere with antibody binding in people who have been exposed to the SARS-CoV-2 virus in the past. At the moment, there is very little information on the Omicron version. Therefore, mutation dispersion evaluations, evolutionary links to previous variants, and putative structural effects on antibody binding effects are all explored in this work. Results: In the current state of pandemic crises, the comprehension of Omicron will pave a path for healthcare professionals to treat infectious conditions very well.
ABSTRACT
COVID-19 since its inception from the month of December 2019 has been associated with myriads of systemic complication apart from the respiratory failure, with Guillain-Barre syndrome (GBS) being one of the prominent neurological complication. More than 220 patients with GBS have been reported thus far. We wish to share 3 cases of GBS associated with COVID 19 admitted in our institute. GBS is one of the most common causes of acute, acquired weakness and is often provoked by a preceding infection, which triggers an immune response, cross-reacts with shared epitopes on peripheral nerve (molecular mimicry). Interestingly one of the cases developed limb weakness concurrently with the respiratory symptoms, probably during the viremic phase;the other 2 cases few weeks after recovering from COVID 19. So, is there a specific association with covid 19 and GBS? If associated, is it Para infectious or Post infectious? Further studies are needed to unravel its association with COVID 19. © 2022 Journal of Medical Society.
ABSTRACT
The aim of this paper is to conduct a bibliometric study to investigate the research output of library and information science in India. The SCOPUS database was selected to collect data from 2011 to 2020. Collected data was analysed on various parameters such as authorship pattern, year wise contribution of articles, most cited articles, top journals, top authors, document types, etc. The study found that in year 2019 Indian author contributed 471 research papers which 21.8% and highest in 10 years. Again in 2019, double authored article was highest in number with total of 252 articles. In periods of 10 years, about 2159 Indian articles were published with international collaboration. The growth of LIS research has been observed to bincreasing till 2019, but decrease in 2020 possibly due to the Covid pandemic. © 2021, Library Philosophy and Practice. All Rights Reserved.